CLINICAL PHARMACOLOGY OF BRETYLIUM TOSYLATE: PRELIMINARY OBSERVATIONS
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چکیده
منابع مشابه
Prevention of chronic canine ventricular tachyarrhythmias with bretylium tosylate.
The ability of chronic bretylium tosylate treatment to prevent the induction of ventricular tachycardia was assessed in the conscious dog subjected to serial programmed ventricular stimulation on days 3-6 after acute myocardial infarction. In 34 untreated control dogs, programmed ventricular stimulation produced nonsustained ventricular tachycardia in 11 dogs (32%), sustained ventricular tachyc...
متن کاملBretylium tosylate in prevention of cardiac dysrhythmias after myocardial infarction.
The prophylactic value of parenterally administered bretylium tosylate against the onset of dysrhythmias after acute myocardial infarction has been assessed by a controlled trial in 101 male patients. Bretylium significantly reduced the incidence of supraventricular dysrhythmias but was without significant effect on the incidence of ventricular dysrhythmias. The only serious side-effect of the ...
متن کاملEffect of bretylium tosylate (Darenthin) on pulmonary circulation.
BRETYLIUM tosylate (Darenthin, Burroughs Wellcome), is one of the series of benzyl quaternary ammonium compounds which blocks selectively the peripheral sympathetic nervous system without antagonizing the effects of epinephrine. This block occurs without depression of the parasympathetic or central nervous system.' Its effect on the pulmonary circulation has not hitherto been investigated. ,_ ....
متن کاملEffectiveness of bretylium tosylate against refractory ventricular arrhythmias.
Thirty patients with ventricular tachyarrhythmias, which had not responded to intensive therapy with up to five antiarrhythmic drugs, were treated with bretylium tosylate. All patients had recurrenit ventricular tachycardia, and 12 had repeated episodes of ventricular fibrillation. In 17 patients the arrhythmias followed acute myocardial infarction. Bretylium was administered intramuscularly or...
متن کاملExperience with bretylium tosylate by a hospital cardiac arrest team.
The effect of bretylium tosylate (BT) was determined in 27 consecutive cases of resistant ventricular fibrillation (VF) encountered by a hospital cardiac arrest team. The VF was sustained and completely resistant to multiple injections of lidocaine, sequential DC shocks at 400 watt-sec and one or a combination of intravenous propranolol, diphenylhydantoin or procainamide. Following 30 min of su...
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ژورنال
عنوان ژورنال: Annals of the New York Academy of Sciences
سال: 2006
ISSN: 0077-8923
DOI: 10.1111/j.1749-6632.1960.tb20087.x